Blocking T-cell negative signal reduce tumor burden to minimal

Antibodies to merkel cell polyomavirus T antigen oncoproteins reflect tumor burden in merkel cell carcinoma patients.

Merkel cell polyomavirus (MCPyV) is a common infectious agent that is likely involved in the etiology of most Merkel cell carcinomas (MCC). Serum antibodies recognizing the MCPyV capsid protein VP1 are detectable at high titer in nearly all MCC patients and remain stable over time. Although antibodies to the viral capsid indicate prior MCPyV infection, they provide limited clinical insight into...

Mir-55 inhibition can reduce cell proliferation and induce apoptosis in Jurkat (Acute T cell Leukemia) cell line

Background MicroRNAs are small and non-coding RNA molecules with approximately 22 nt in length that cause inhibition of translation or degradation of mRNA. MiR-155 is a kind of molecule with different functions, such as its role in proliferation, apoptosis, inflammation, differentiation, and immunity. One of its best known functions is apoptosis that affects on caspase-3 activity. The main aim...

Inhibition of Tumor Promotion through Blocking Signal Transduction

67 INTRODUCTION 67 MOLECULAR MECHANISM OF TUMOR PROMOTION BY TPA 68 TPA activates phosphorylation of serine/threonine 68 TPA induces oxidative stress 69 TPA activates early response genes 71 ANTI-CARCINOGENESIS OF SEVERAL NATURAL POLYPHENOLIC COMPOUNDS 72 CURCUMIN INHIBITS TUMOR PROMOTION THROUGH BLOCKING SIGNAL TRANSDUCTION 73 DISCUSSION 74 ACKNOWLEDGEMENTS , 74 REFERENCES 74 CHINESE ABSTRACT 81

Response to a Solid Tumor Signal 3 Availability Limits the CD 8 T Cell

Smoothing T cell roads to the tumor

We described a novel tumor-associated immunosuppressive mechanism based on post-translational modifications of chemokines by reactive nitrogen species (RNS). To overcome tumor immunosuppressive hindrances, we designed and developed a new drug, AT38, that inhibits RNS generation at the tumor site. Combinatorial approaches with AT38 boost the effectiveness of cancer immunotherapy protocols.